Pharmaceutical compounds, preparation, use and int

专利名称：Pharmaceutical compounds, preparation,

use and intermediates therefor and theirpreparation

发明人：Lawrence A. Lowe,Terence W. Smith,Samuel

Wilkinson

申请号：US06/463935申请日：19830204公开号：US04489062A公开日：19841218

摘要：Novel peptides of formula (I)

X--Tyr--X.sup.2 --Gly-- Phe(4NO.sub.2)--Pro--NH.sub.2 (I)

and salts thereof, wherein X is hydrogen or an amidino group and X.sup.2 is a radicalselected from D-S-methylmethionyl and D-arginyl, have a selectively peripheral analgesiceffect when administered to mammals.< P>< P>The compounds also exhibitantidiarrhoeal and antitussive activity and may thus be used in human or veterinarymedicine for the relief or prevention of pain, for the treatment of diarrhoea or dysenteryand for the suppression of cough.

申请人：LOWE; LAWRENCE A.,SMITH; TERENCE W.,WILKINSON; SAMUEL

代理人：Donald Brown

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