METHOD OF INDUCING CLEAVAGE OF AMYLOID PRECURSOR P

专利名称：METHOD OF INDUCING CLEAVAGE OF

AMYLOID PRECURSOR PROTEIN TO FORM ANOVEL FRAGMENT

发明人：OLTERSDORF, TILMAN,WEBER,

ECKARD,GREEN, KIM, NICHOLAS

申请号：EP09836830申请日：20091215公开号：EP2361088A4公开日：20120530

摘要：The present invention provides a method of inducing cleavage of amyloidprecursor protein to produce an approximately 17 kilodalton carboxy-terminal fragmentof amyloid precursor protein in a subject, the method comprising administering aheterocyclic compound or a pharmaceutically acceptable salt, hydrate or prodrugthereof to a subject in need thereof, wherein the approximately 17 kilodalton fragmentincludes the carboxyterminal amino acid sequence of amyloid precursor protein andamyloid-beta amino acid sequence. Also provided is a screening method for identifyingcompounds induce cleavage of amyloid precursor protein to produce the approximately17 kilodalton carboxy-terminal fragment of amyloid precursor protein.

申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA,ZENYAKU KOGYO CO.,LTD

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