ENHANCEMENT OF THE EFFICACY OF THERAPEUTIC PROTEIN

专利名称：ENHANCEMENT OF THE EFFICACY OF

THERAPEUTIC PROTEINS

发明人：GROBLER, Anne Frederica,KOTZE, Abraham

Frederik,DU PLESSIS, Jeanetta

申请号：EP08789190.9申请日：20080704公开号：EP2194970B1公开日：20150902

摘要：The invention provides a formulation for the administration of at least onetherapeutic mammalian protein to a mammal, and for enhancing the absorption,distribution and release of the at least one therapeutic mammalian protein in or on themammal, the formulation consisting of at least one therapeutic mammalian protein in amicro-emulsion which micro-emulsion is constituted by a dispersion of vesicles or

microsponges of a fatty acid based component in an aqueous or other pharmacologicallyacceptable earner in which nitrous oxide is dissolved, the fatty acid based componentcomprising at least one long chain fatty acid based substance selected from the groupconsisting of free fatty acids and derivatives of free fatty acids It further provides amethod of the effective delivery of at least one therapeutic mammalian protein to amammal and for enhancing the therapeutic efficacy of such at least one therapeuticmammalian protein, the method comprising the step of administering the at least onetherapeutic mammalian protein to the mammal in such a formulation

申请人：UNIV NORTHWEST

地址：ZA

国籍：ZA

代理机构：Bates, Philip Ian

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