专利名称：THERAPEUTIC AGENTS FOR THE
TREATMENT OF DISEASES ASSOCIATEDWITH UNDESIRED CELL PROLIFERATION
发明人：SEOANE SUAREZ, Joan,PENUELAS PRIETO,
Silvia,BASELGA TORRES, José
申请号：EP10713619.4申请日：20100406公开号：EP2414394A2公开日：20120208
摘要：The invention is based on observing that LIF is capable of activating the self-renewal of tumor stem cells in cancer, in particular gliomas, which indicates that theinhibition of LIF, and generally of IL- 6 type cytokines, can be used in therapeuticcompositions for the treatment of diseases associated with unwanted proliferation. Theinvention also relates to a method for the identification of compounds capable ofblocking/inhibiting the proliferation of stem cells, and to an in vitro method for thediagnosis of diseases associated with unwanted cell proliferation in a subject or fordetermining the predisposition of a subject to suffer said disease associated withunwanted cell proliferation, or for prognosis of average life expectancy of subjectssuffering from said tumors.
申请人：Fundació Privada Institució Catalana De Recerca I Estudis Avançants,FundacióPrivada Institut d'Investigació Oncològica de Vall d'Hebron,Fundació Privada Institut DeRecerca Hospital Universitari Vall Hebron
地址：Passeig Lluís Companys 23 08010 Barcelona ES,Passeig Vall d'Hebron 119-129
Edifici Matern-Infantil, Planta 14 08035 Barcelona ES,Passeig Vall d'Hebron 119-12908035 Barcelona ES
国籍：ES,ES,ES
代理机构：HOFFMANN EITLE
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